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I am only a couple hours in, so bear with; these are my first impressions.
First, I have several criticisms:
1) The download
1.7 GB doesn't sound bad, but it does take a while at between 2-3 kbps. Once the updater installed, I had to go through a number of large patches that took up almost half the day. I was able to run several errands before coming back to find the game was finally ready for launch. This is a commitment in an age where there are games I could play in my browser and games that have "rolling downloads" that install only parts of the game I will have access to at the beginning, etc. The wait is the main thing; not a huge issue, but I thought that I would point out it is a commitment.
2) The UI feels cluttered. A lot of real estate on my screen is taken up by what look like empty inventory / ability slots. I want to see more of the world, which to me is the 3D environment.
3) Graphics feels somewhat dated... not a huge issue, but I definitely noticed some rasterisation on the tree outside the Gene Replicator in the starting area.
Now that that's out of the way;
The game did a great job of making it feel like there was a lot going on, and that I was taking my first steps into a huge world. The player-housing is a very nice touch. Kind of "Blade Runner" meets "The Matrix". I had 5 emails I had to check when I first got to my apartment unit. It was kind of funny that I had to wait to get to my apartment to check my emails, but that's another story. I spoke to a guy who looked a lot like Morpheus who said I had to steal some data for him, and that I had 3 days to do so (nice touch!). I took a look at the world map; there's definitely a giant, gritty world out there.
I didn't get into any combat right away, and that kind of has me worried; I know there's a chip or something I can take out to participate in PvP, but I had no indication of what said PvP would involve, only a warning that I would probably get Pwned unless I was in a clan.
I had the chance to step inside the Hacknet, which was an appropriately trippy experience. It looked like something out of "Tron", the original. I'm looking forward to seeing what else I can do there.
The UI is definitely going to take some getting used to; I just wish it was... smaller, more minimal. It's almost as if the devs are hiding what there is to see from me. 2 hours in and still no combat, which is disappointing because I've heard Neocron virtually pioneered the FPS MMORPG genre. Otherise the game feels moody, atmospheric; like I stepped right into a Cyberpunk novel or a movie by the Wachowski brothers.