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Haven't played any paper and dice roleplaying in about oh about 20 years (the cumbersome 2nd edition was in its heyday) so I can't comment on D&D 4th edition and the fact that they wow'ed-down the rules to the ire of manys-a-gamer but I'd like to know what they can possibly bring from the paper and dice format to this game when, from what we know:
Gameplay: it's action based, not turn based and dice roles don't appear to play a big part in moment to moment actions (compared to Baldurs/Neverwinter Nights etc)- so, where you point your cursor you shoot, even more so than GW2.
Stats: I can see how stats like Con can affect your healthbar but what about stats like Dex? It can't really affect your ranged if the player's mouse skill determines the hit rate.
Classes: not really distinct from other games since they've been aped to death and stats can't seem to affect combat.
Foundry: ok, so, like Neverwinter Nights, you can create content to a certain extent by designing your own quests/Dungeons. So there's a hint of a DMing feel about that I grant you.
Conclusion: the only resemblance to D&D will be the classes, the races, the neverwinter setting and the trademarked spell names?