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First off ...
Okay take a look at the Blizzcon 2011 poster here and look at Diablo in the middle. That certainly looks more female than male to me. So if you were wondering how they were gonna bring him back, i guess we now have a pretty good idea.
It looks like Leah, as seen in the Black Soulstone cinematic, will be the prime candidtae. I guess only a prime evil can deal with Azmodan... and us players of course ;p
So yea ... Leahblo?