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I have played WOW since release, and many other MMO's before that, and have found that after "however many 1,000's of quests" i have done, I simply cannot do another quest. If an NPC asks me to walk across the room and talk to Jim the Cook and receive an epic weapon and 20,000 experience points, I find I just cannot (will not) do it.
Emptied out my quest log today, even. Maybe every game has its playability limits.
In the future, I think I will look for games that have few or no quests. For me, the quest-grind is the worst grind of all.
Anyone else out there feel the same?