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I'm looking for, as the title suggests, a PvE focused game that is not quest driven. Basically, I don't like it when a game holds my hand all the way through, just following the arrows to the level cap. I also don't like open PvP, as it tends to end up as a gankfest. I don't like ganking others and I don't like worrying about it when doing the stuff I do like, so I'm looking for something PvE focused.
My other criteria are as far as combat goes, I cannot stand hotkey rotation. It just puts me to sleep. Instant deal breaker. Graphically I don't like western cartoony or post apocalyptic, but about anything else is fine. I also tend not to like dungeon crawlers, but mainly because they end up being just a race to the boss and nothing else and it ends up feeling similar to quest arrows. I'd consider one that does things differently, but if you do suggest one please tell me why it's different.