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Only used a HOTAS myself but there are plenty of people on the forums using mouse and keyboard.
One of the devs stated that changes are to be made as they're not happy with where m / kb is right now.
Control layout - https://forums.frontier.co.uk/showthread.php?t=18465
Supposedly it has a decent voice control system as well.
I saw a streamer that was using it for landing gear, targeting and other things of that nature.