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The old Shadowbane developers used OpenGL in their game engine. They also used Commodore 64's in their server cluster. Their server cluster was powered by hamsters.
Another thing that cause Shadowbane to fail may of been something that the average player or outsider could not see. Money. The original Shadowbane developers were gamers that wanted to do something amazing. However look at it this way. Look at yourself right now (yes, you). Can you stop what you are doing right now and start developing a game? Including finances, programming, design, art, music, etc etc etc? Most likely not.
Lets look at another game that had a real plan in place for its game: Darkfall. It was developed for 10 years. The company used other projects to fund itself and continues to do so. Darkfalls finances are so good that, even with its flaws (being FPS in a MMORPG market, its biggest flaw) and low sub count they are expanding their development team and have been working on a relaunch of the game for almost two years. That is a solid financial plan in the background. They are making the game they want in a really niche market and being successful at it.
If a development company had a good solid financial plan I bet they could make tons of money off of a Shadowbane 2, maybe even more so than Darkfall. Darkfall is in a different but similar niche market than Shadowbane (most MMO players have limited FPS skills, like myself). So why not try?
The definition of insanity: doing the same thing over and over expecting different results.