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I was trying to think of why I quit EQ2, Vanguard, WAR, and (periodically) WOW, and the point of annoyance that brought me to each decision was when I found myself loaded up with tons of mundane quests and no desire to do them.
Rare quests are exciting. A few quests are still cool. But stacks upon stacks of quests become a chore.
Don't do quests, you say? Well, all folks tend to follow the path of least resistance, and so feel compelled to do these quests, but that doesn't mean they like it.
Just like if someone threw a bunch of one dollar bills in the air, people might drop to their hands and knees to pick them up, but again that doesn't mean they enjoyed it.
I, for one, am hoping new MMORPG's scale back on the quests. Having a quest log with 20 quests to do is not fun for many.