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already have an issue and normally i would search the forums for a game to get the answer but - oh yeah..........
anyway - can't find settings for left-handed mouse
most games (or should i say correctly programmed) games use the PC settings for the mouse so the end user doesn't have to go screwing around trying to make alterations immeidately
tried things title UI settings - bindings and interface but haven't found anything except for Invert Mouse which wasn't it