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The fact that Runescape uses a browser based design it great on many fronts, the game is easy to get into, easy to play for 10 minutes on and off, and is a good starting place for MMO gamers.
The ways in which such a simple system can be preyed upon by autoers are so numerous, that the game has a bot population rivaling that of any other game in existence. The fact that the only thing connecting the server and the players computer is an application running in internet explorer, rather than a full out client which moniters other programs running as well as keeping track of the actions of users in a much more in depth method.
I realize that Jagex stands for JAva Games EXperts, but in all honesty i see this as the only way to truly limit autoing and RMT, to upgrade the client to a modern level (without nerfing the gameplay at all).
plus on the bright side, i for one would love nothing more than 3D runescape with WASD and good graphics