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Im going to compare WildStars combat to WoW (and most games that derive their combat from that). If youve read this post and think what im describing is a bad system, id love to hear why.
In WildStar you can tab to select targets, but you can only lock onto them (if you chose) in PvE. In PvP you have to manually face your target at all times. In WoW you always lock onto the target, so wherever they move as long as they are within range of your attacks and there are no line of sight issues you can hit them.
In WildStar all attacks can be dodged. For instance, if something fires a Fireball at you you can move out of its way. In WoW you cannot through player skill dodge attacks. All attacks are dodged through the game calculating a hit/miss.
In WildStar most (or all) attacks have an AoE effect. So your default attack hits whats in front of you in an area resembling a thin rectangle. Meaning if there is more than one target in front of you you will hit them both. So if there is an enemy to the left of you and one to the right of you, you could reposition yourself to attack both at the same time. In WoW all attacks except those designated as AoE will attack only 1 target only. So when you shoot a Fireball, if there are things between you and your target that Fireball will fly THROUGH them and then only hit the target you had selected.
In WildStar you can only bring 8 offensive skills to a fight. So even though at level 50 you will have 30+ skills, you have to pick and chose which skills you like or want. You can change this outside of combat freely, but once youre in combat youre locked to your choices. This especially in PvP makes the flow of combat significantly smoother as there isnt a massive diarrhea of abilities being used by each player. In WoW all skills/spells are available at all times once you get them, forcing you to manage 20+ skills at the same time to be truly effective (for most classes, Rogues get off easy).
In WildStar you have interrupt armor which has to be knocked off first before you are vulnerable to crowd control abilities. Bosses can also be crowd controlled, but require multiple players to coordinate. In WoW anyone can crowd control you at any time, and youre welcome to roam the world sheeped, blinded, rooted, disarmed, feared and poisoned. There are diminishing returns on subsequent CC's.