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Overall I give the game a solid 7/10. It's certainly worth the buy in my opinion but, while theres a lot to like there are some glaring issues that need to be fixed prior to launch.
Lets start off with what I liked
Graphics - These aren't cutting edge but the game looks good.
Gameplay - Minus the UI, Control, and camera issues I'll expand on later the gameplay is rather enjoyable. Its fast paced and fun. I also like that many of the mobs have weak points that you need to hit to bring it down or bring them down faster. Hitting the weak points can be the difference between doing 1k damage a hit vs. doing 40 dmg a hit. Some can only be damaged by hitting the weak points.
Content - Theres a variety of things to do. You have the main story missions, side missions, random events out in the world, Arkfalls, time challenges, and PvP. Theres even a lot of variety in each of those themselves. Time trials can have you racing on an ATV, killing waves of mutants, and etc. Challenge and difficulty can vary from activity to activity and some of it scales with the number of players doing it with you. ArkFalls are especially fun for me. They are better versions of Rifts from Rift.
Depth and Customization - On the surface the game seems fairly simplistic with limited customization options. Once you get deeper into the game though things start to open up. Character creation was fairly limited but you start gaining a number of outfits that let you really tailor your look to your liking. I saw some suits and headgear that I really want but I'm sure those were alpha testers wearing them. Weapons themselves offer a great deal of variety and customization options. Each weapon type has a variety of sub types within them. A rocket launcher can be a heat seeking lock on weapon, a weapon that fires a single rocket that explodes and shoots out several smaller projectiles that do damage in a wider area or a number of other types of rocket launchers. To top that off you can add mods that change things up even more. The EGO system is another area where it seems limited but offers a great deal of customization through the perks. You can really tailor it to your play style.
Uniqueness - There really aren't any or many Persistant Massive multiplayer online Third person PvE centric shooters out there. The show tie in makes it even more unique. It does borrow elements from some newer MMOs which helps as well. All in all there really isn't anything out there like defiance, some games are some what similar but not really like it. Firefall is some what similar but only in minor ways. It also lacks the production quality, focus, depth, and content. Beyond that Defiance is pretty much the first of its kind :P
Now, things I really didn't like
Contols/UI - This is awful. It is in no way shape of form designed with PC in mind. Its counter intuitive to say the least. Alt to dodge, shift is a sprint toggle, to get to the log out menu you have to press F6, esc brings up your character screen, etc. Its just completely different from what has become the standard in PC games let alone MMOs. It really needs to have a lot of thought put into it and completely changed.
Sound - Most of the sound and music is decent but... some of the vehicle sounds are to high pitched and the crashing sound is awful. The music lacks variety and the main song that loops has this faint sound in the background that sounds exactly like my phone while it rings when I'm wearing my headphones. I hope this gets changed before launch. They aren't deal breakers but they are annoying to me.
Camera - My character feels way to far to the left. In close combat it messes with my aiming a lot. I do get use to it but as soon as I play another TPS game when I come back to defiance I have to relearn how to aim and play again. Some will get nauseous from the field of view as well. I didn't but this is the type of thing that does effect some.
One Way Scaling - While I like that some of the content scales, I dislike that its a one way street lol. I had an Arkfall event where several players came in to help and the difficulty increased. They left to go do something else and I was left to finish it alone. However it didn't scale back down. I was left with some pretty difficult mobs and a great number of them and they kept respawning. I had to eventually abandon the Arkfall. I hope this gets fixed prior to launch.
Chat - Hitting enter should bring up chat, it does not (Though this may be a bug for me as it seems like it is supposed to bring up chat). I actually had to go into a menu to find the chat box lol. I haven't talked to anyone in game because its to much effort to do so. I'm not sure what the deal with the chat system is but... I really hope this is fixed and brought more inline with the standard in MMOs.
The lack of Banks/Storage - I have no means of storing anything that I'm aware of besides in my inventory. I hope this is going to change prior to launch. All the mods I couldn't currently use that I've come across that I may want to use later fill up my inventory fast. It really would be nice to have some place to store this kind of stuff.
VOIP - Quality is awful, no push to talk option, and its set to on by default. This has made for some annoying times in game. This is a must fix type of thing.
It may seem like I should rate the game lower due to the amount of negatives vs. positives but the fun factor and the level of depth and customization I found makes up for a lot. The lack of a monthly fee helps slightly as well.
Like I said, I certainly believe its worth the buy but.. it also has a number of issues that they really need to address.