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We know Neverwinter is based off the AD&D 4.0 edition (yuck) which greatly removes the freedom of AD&D skill based class system. I myself am greatly hoping there is multi classing allowed at release. Being forced to play a rigid class greatly influences my likeability of a game.
I never played 4.0 but from looking at the wiki it appears there are some hybrid style classes http://en.wikipedia.org/wiki/Character_class_(Dungeons_%26_Dragons)#4th_edition
Hoping that Swordmage and Avenger make the cut. I am also looking forward to see if Paragon paths make the cut as well, which would greatly open up the rigid class system to some more hybrid like gameplay.
Waiting on: TESO
Next Flop: Planetside 2
Best MMO of all time: Asheron's Call - The first company to recreate AC will be the next greatest MMO.