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The logistics requirements for such a game being quite extraordinary, the rest of the features will be too.
Imagine a MMORPG with a world the size of the USA in which you'd play a "regular" human character. Not unlike Second Life, in a way, only with total freedom : you would play by being in the game, just like in those crazy video game dev dreams. It would use some sort of implant that would allow you to play the game while your body would stay in a sleep-like state. You could do whatever you want, just like in real life. And more, obviously.
To purchase the game, you would need to go though a lot of identity checks as to avoid people buying it twice. To enforce such a system, it would probably have to be run by governments or a single company at a very limited number of stores (to limit a black market of sorts). You could only buy it once in your lifetime.
You would play a single character, and there would be permadeath: you die, you can't play the game ever again. To let viable societies emerge, permadeath would only be activated a month after release.
There would be no skill system, no levels, nothing like that. You're playing a character that has human strenght and abilities piloted by your intellect.
Would you play such a game ?