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I just picked up a bunch of games from Steam the Autumn Sale, so storage space has cropped up as an issues for me. In looking at my HD, I've had to make some hard decisions.
At present I have:
When Darkfall: Unholy Wars comes out, hopefully 12-12-12, I will delete one of those three. It will probably be on my HD for a while as I'm very patient with games if I like the concept (see TSW) even if its fubar at the beginning. I love Darkfall's concept.
I just uninstalled Planetside 2 (I have BF3 for fps shooters and I'm enjoying the hell out of Chivalry: Medieval Warfare -- never laughed so hard in pvp when getting my head or arm lopped off by a friend and getting him back later), even though I have 5000 station cash. I can always go back and check it out later.
What do you have on your HD right now?