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Are you a AA or AAA developer looking to produce a game with mass appeal? You should take a good hard look at the space setting. I am not saying that you should make "WoW in space" but on a spectrum there is loads of room between what Eve is and what WoW is. And dear god not SWTOR.
Take a good hard look at Eve online and all of the things that are keeping it a niche game. I think you will find that if you can capitalize on the things that CCP refuses to look at year after year you will find yourself a profitable venture.
A game that offers reasonable challenge and content without the constant "risk" of pvp would do well. A game that captures the imagination of space enthusaists without the their absoultely depressing vision of warfare and destruction as a centre theme would do well. That is not to say that these could not be aspects of warfare in a space setting universe.
Space themed games are a woefully under utilized opportunity. I would say that comosologists turned programmers would make the best candidates for the type of game i'm talking about. Someone who can take a look at the marvels of space and turn them into a UO'esque or even EQ 'esque setting would do well.
Just don't ever try to run player elected governments and shun the idea of an organization like Goonswarm being in your game setting at all and you would find yourselves in an advantage.