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I can already see the Sneak Thiefs will run away with this thread but lets see what people like.
I personally enjoy the 2Handed Battle Axe + Destruction magic in Light Armor for avoidance and Stamina Regen. Really love opening up with a few Incinerates from range and finish them off with a couple Backwards Power Attack. Such a wonderful feeling of control with that setup. I would without any other knowledge probably play a Sorcerer with 2H and Medium Armor (Skyrim's version of light) so I can get this same playstyle.
Lets hear what your's will be.