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it is all class specific. For example, if you have a rogue, would you like your stealthy assasin weilding a GIANT 2h'er? or a dagger in each hand, designed for fast swift attacking with a lower amount of damage.
If you have a warrior on the other hand, a 2H'er is more ideal, due to the fact that they are about power, and not speed. A 2 handed weapon deals more power, so Warrior Power + Weapon Power = MOAR POWER!
Rogues have speed + weapon speed = MOAR SPEED resulting in more dps.
It's all preferences. Neither is better than the other.
It all comes down to abilities and what support gems you attach.
I love my 2 hander marauder with Sweep + Life on Hit + Added Cold Damage. I also love my shadow with a 1 hand claw using Whirling Blades.
My advice for melee is build more health and survivability rather than damage. At higher levels you will need it.
all depends on how you build your character