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I started with a Berserker and I'm playing on normal difficulty. I feel overpowered and haven't died yet, and I'm almost level 20. I just hope this doesn't turn out to be another Diablo III with "balance" nerfs shortly after launching the game. They ruined the Monk before I had a chance to play through Diablo III.
So, what class are you playing as, and how are you enjoying it? Do you feel powerful for the difficulty level you are on?