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Based on the nature of the game , it would be nice is curses diseases existed that lay dormant and if you don't go for a checkup they can spread.
This could be quite ammusing if a PUG group forms or even if someone within a guild has a disease or curse that is transferable when grouping. Could be quite ammusing also if this is sort of a global quest for everyone in the game and until the cure is found , half or more of the server population could have debilitating effects. And the rest either in quarantine or very wary as to who they allow to join with them.
Ongoing maladies that need more than a single spell to sure to me would add depth and variety to the game and stooryline.
These would not be game stopping as this would required very strong communities to play through but just minor ailements which last until cured or the citadel provides vaccinations.
[Edited for spelling]
Sorcery must persist, the future is the Citadel