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To get things started, I am not a tank. So, I am sure those classes have a bit easier time handling such situations.
Ellyrion is my major gripe. I am a Dark Elf and I primarily PvE this area while I wait for T2 scenarios to pop, or get tired of playing said scenarios. It is by far the most frustrating game experience. It is a beautiful zone, but the way mob placement was done here is enough to make no desk safe from fist smashing.
Simply put, there are FAR too many roaming mobs, and mobs in general in this zone. I cannot accomplish anything while attempting quests. NPCs riding on horseback crisscross each other and cover ground that completely inhibits solo play. General mob spawns are also so dense, I can't contemplate how they would tolerate had they been sentient.
Once I finally fight through the 3 dozen mobs (hardly exaggerating) to get to the one quest objective, I find 2-3 roaming mobs walking directly to the area in which I am fighting. I end up giving up the fight, only to be snared/rooted while 3 mobs that never used to be there, have their way with me. I will respawn and start all over again, only to receive the same result.
I've taken the slow, paranoid approach when questing. One mob at a time, slowly but surely, don't aggro more than one. I don't attempt to bypass content. WoW's horrible AI and game mechanics trained me to quest that way (here are 13 mobs that will respawn and daze you 30 seconds after you kill them). But it is simply unavoidable in this game.
If there has to be one change in PvE gameplay, I would love to see nothing more than a complete mob placement overhaul. It is getting ridiculous.